Time Zone – GMT-4 (America/New_York)
| 1 | MLS All-Stars | Liga MX All-Stars |
| Pl | W | D | L | Diff | Pts | |||
| 1 | San Diego FC | 20 | 12 | 3 | 5 | 41:25 | 16 | 39 |
| 2 | Vancouver Whitecaps | 20 | 11 | 5 | 4 | 35:22 | 13 | 38 |
| 3 | Minnesota United | 21 | 10 | 7 | 4 | 35:24 | 11 | 37 |
| 4 | Portland Timbers | 19 | 8 | 6 | 5 | 28:27 | 1 | 30 |
| 5 | Seattle Sounders | 19 | 8 | 5 | 6 | 27:25 | 2 | 29 |
| 6 | San Jose Earthquakes | 20 | 7 | 6 | 7 | 40:32 | 8 | 27 |
| 7 | Los Angeles FC | 17 | 7 | 5 | 5 | 30:24 | 6 | 26 |
| 8 | Colorado Rapids | 21 | 7 | 5 | 9 | 24:30 | -6 | 26 |
| 9 | Austin FC | 20 | 7 | 5 | 8 | 15:23 | -8 | 26 |
| 10 | Sporting Kansas City | 21 | 6 | 5 | 10 | 33:38 | -5 | 23 |
| 11 | Houston Dynamo | 20 | 6 | 5 | 9 | 25:31 | -6 | 23 |
| 12 | FC Dallas | 20 | 5 | 6 | 9 | 27:37 | -10 | 21 |
| 13 | Real Salt Lake | 19 | 5 | 4 | 10 | 19:26 | -7 | 19 |
| 14 | St. Louis City | 20 | 3 | 6 | 11 | 19:31 | -12 | 15 |
| 15 | Los Angeles Galaxy | 21 | 2 | 6 | 13 | 22:42 | -20 | 12 |
| Pl | W | D | L | Diff | Pts | |||
| 1 | Philadelphia Union | 20 | 12 | 4 | 4 | 35:20 | 15 | 40 |
| 2 | FC Cincinnati | 20 | 12 | 3 | 5 | 31:26 | 5 | 39 |
| 3 | Nashville SC | 20 | 11 | 5 | 4 | 36:23 | 13 | 38 |
| 4 | Columbus Crew | 20 | 10 | 7 | 3 | 33:26 | 7 | 37 |
| 5 | Orlando City | 20 | 9 | 6 | 5 | 37:26 | 11 | 33 |
| 6 | New York City | 20 | 9 | 4 | 7 | 27:22 | 5 | 31 |
| 7 | Inter Miami | 16 | 8 | 5 | 3 | 36:27 | 9 | 29 |
| 8 | New York Red Bulls | 20 | 8 | 5 | 7 | 32:24 | 8 | 29 |
| 9 | Chicago Fire | 19 | 8 | 4 | 7 | 38:34 | 4 | 28 |
| 10 | Charlotte | 20 | 8 | 1 | 11 | 32:34 | -2 | 25 |
| 11 | New England Revolution | 18 | 6 | 6 | 6 | 24:21 | 3 | 24 |
| 12 | DC United | 20 | 4 | 6 | 10 | 17:39 | -22 | 18 |
| 13 | Toronto FC | 20 | 4 | 5 | 11 | 23:28 | -5 | 17 |
| 14 | Atlanta Utd | 19 | 4 | 5 | 10 | 22:37 | -15 | 17 |
| 15 | CF Montreal | 20 | 3 | 5 | 12 | 17:36 | -19 | 14 |
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