Time Zone – GMT-4 (America/New_York)
| 1 | MLS All-Stars | Liga MX All-Stars | 3 : 1 |
| Pl | W | D | L | Diff | Pts | |||
| 1 | San Diego FC | 26 | 15 | 4 | 7 | 50:32 | 18 | 49 |
| 2 | Vancouver Whitecaps | 25 | 13 | 6 | 6 | 43:28 | 15 | 45 |
| 3 | Minnesota United | 26 | 12 | 8 | 6 | 43:30 | 13 | 44 |
| 4 | Seattle Sounders | 25 | 11 | 8 | 6 | 43:35 | 8 | 41 |
| 5 | Los Angeles FC | 23 | 10 | 7 | 6 | 41:30 | 11 | 37 |
| 6 | Portland Timbers | 25 | 10 | 7 | 8 | 33:34 | -1 | 37 |
| 7 | Austin FC | 24 | 9 | 7 | 8 | 23:28 | -5 | 34 |
| 8 | Colorado Rapids | 26 | 9 | 6 | 11 | 33:40 | -7 | 33 |
| 9 | San Jose Earthquakes | 26 | 8 | 8 | 10 | 49:45 | 4 | 32 |
| 10 | Real Salt Lake | 25 | 9 | 4 | 12 | 27:32 | -5 | 31 |
| 11 | FC Dallas | 25 | 7 | 7 | 11 | 37:45 | -8 | 28 |
| 12 | Houston Dynamo | 25 | 7 | 7 | 11 | 32:41 | -9 | 28 |
| 13 | Sporting Kansas City | 25 | 6 | 6 | 13 | 36:47 | -11 | 24 |
| 14 | St. Louis City | 25 | 5 | 6 | 14 | 27:41 | -14 | 21 |
| 15 | Los Angeles Galaxy | 25 | 3 | 7 | 15 | 28:52 | -24 | 16 |
| Pl | W | D | L | Diff | Pts | |||
| 1 | Philadelphia Union | 26 | 15 | 6 | 5 | 44:25 | 19 | 51 |
| 2 | FC Cincinnati | 26 | 15 | 4 | 7 | 39:32 | 7 | 49 |
| 3 | Nashville SC | 26 | 14 | 5 | 7 | 43:29 | 14 | 47 |
| 4 | Orlando City | 26 | 12 | 8 | 6 | 50:34 | 16 | 44 |
| 5 | Columbus Crew | 25 | 12 | 8 | 5 | 41:36 | 5 | 44 |
| 6 | Inter Miami | 23 | 12 | 6 | 5 | 50:38 | 12 | 42 |
| 7 | Charlotte | 26 | 13 | 2 | 11 | 44:39 | 5 | 41 |
| 8 | New York City | 24 | 11 | 5 | 8 | 34:29 | 5 | 38 |
| 9 | Chicago Fire | 25 | 10 | 6 | 9 | 47:42 | 5 | 36 |
| 10 | New York Red Bulls | 26 | 10 | 6 | 10 | 41:37 | 4 | 36 |
| 11 | New England Revolution | 25 | 7 | 7 | 11 | 33:35 | -2 | 28 |
| 12 | Toronto FC | 25 | 5 | 7 | 13 | 26:33 | -7 | 22 |
| 13 | Atlanta Utd | 25 | 4 | 10 | 11 | 30:46 | -16 | 22 |
| 14 | CF Montreal | 26 | 4 | 7 | 15 | 24:47 | -23 | 19 |
| 15 | DC United | 26 | 4 | 7 | 15 | 22:51 | -29 | 19 |
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